Wilkinson T J, Warren M R
The Princess Margaret Hospital and Christchurch Hospital, Christchurch, New Zealand.
Intern Med J. 2003 Jan-Feb;33(1-2):14-7. doi: 10.1046/j.1445-5994.2003.00328.x.
There is reduced survival for people with all types of anaemia and it has been shown that there is a low yield from investigations for older people with normocytic anaemia. However, the longer-term outcomes of people with mild normocytic anaemia are not known.
To determine the 5-year prognosis of older people with mild normocytic anaemia, compared with non-anaemic controls.
This was a prospective cohort study, with some retrospective data collection, comparing 52 people aged > or =65 years (haemoglobin 100-119 g/L; mean cell volume 80-99 fL) without an obvious cause at presentation with 52 non-anaemic controls. The incidence of death, new malignancies and significant illnesses was compared between the two groups, 5 years later.
Anaemic patients were less likely to be living at home at baseline. Although survival was lower for the anaemic group at all follow-up times, these differences were not significantly different. Over 5 years, there were no significant differences between groups in the types of problems that developed.
A mild normocytic anaemia in older people, in the absence of an obvious cause, is not associated with significant differences in outcomes but is associated with poorer independence and a trend to lower survival. We suggest it may therefore be a marker of frailty in older people.
各类贫血患者的生存率较低，且已表明对正细胞性贫血的老年人进行检查的收益较低。然而，轻度正细胞性贫血患者的长期预后尚不清楚。
确定轻度正细胞性贫血老年人与非贫血对照者相比的5年预后情况。
这是一项前瞻性队列研究，收集了一些回顾性数据，将52名年龄≥65岁（血红蛋白100 - 119 g/L；平均红细胞体积80 - 99 fL）且就诊时无明显病因的患者与52名非贫血对照者进行比较。5年后比较两组之间的死亡、新发恶性肿瘤和重大疾病的发生率。
贫血患者在基线时居家生活的可能性较小。尽管在所有随访时间贫血组的生存率较低，但这些差异无统计学意义。在5年期间，两组发生的问题类型没有显著差异。
老年人中无明显病因的轻度正细胞性贫血与预后的显著差异无关，但与较差的独立性以及生存率降低的趋势有关。因此，我们认为它可能是老年人虚弱的一个标志。
