Campagnaro E L, Woodside K J, Early M G, Gugliuzza K K, Colomé-Grimmer M I, Lopez F A, Daller J A
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
Transpl Infect Dis. 2002 Dec;4(4):207-11. doi: 10.1034/j.1399-3062.2002.t01-1-01012.x.
Transplant recipients receive a number of immunosuppressive medications that result in an increased risk of infection, including infections with microbes that are normally not pathogenic. We describe a patient with end-stage renal disease who underwent kidney transplantation. Six months postoperatively, he presented with a lesion on his ankle, multiple thigh nodules, and right testicular pain. Biopsy of the ankle lesion demonstrated Pseudallescheria boydii (Scedosporium apiospermum), a common environmental fungus. Following orchiectomy, multiple fungal elements were found that were initially described as Aspergillus species, but later identified as P. boydii. In addition, multiple brain abscesses were found on magnetic resonance imaging. Despite treatment with multiple antifungal medications, the patient died of cardiac dysrhythmia. Current diagnostic and therapeutic alternatives for P. boydii are reviewed.
移植受者会接受多种免疫抑制药物治疗，这会增加感染风险，包括感染通常不致病的微生物。我们描述了一名患有终末期肾病并接受肾脏移植的患者。术后六个月，他出现脚踝部病变、多个大腿结节以及右侧睾丸疼痛。脚踝病变活检显示为博伊德假阿利什霉（尖端赛多孢），一种常见的环境真菌。睾丸切除术后，发现多个真菌成分，最初被描述为曲霉菌属，但后来鉴定为博伊德假阿利什霉。此外，磁共振成像发现多个脑脓肿。尽管使用了多种抗真菌药物治疗，患者仍死于心律失常。本文对目前博伊德假阿利什霉的诊断和治疗选择进行了综述。
