Cantineau A E, Heineman M J, Cohlen B J
Academisch Ziekenhuis Groningen, Oostersingel 114 A, Groningen, Groningen, Netherlands, 9711 XH.
Cochrane Database Syst Rev. 2003(1):CD003854. doi: 10.1002/14651858.CD003854.
Intra uterine insemination (IUI), with or without controlled ovarian hyperstimulation (COH), is one of the treatment modalities offered to couples who have tried to conceive for at least one year (subfertile couples). It has been suggested that increasing the number of inseminations from one per cycle to two might increase the probability of conception.
To determine if there is a difference in live birth or pregnancy rates for subfertile couples using single or double intrauterine insemination in stimulated cycles.
We searched the Cochrane Menstrual Disorders and Subfertility group trials register (searched 8 July 2002), the Cochrane Controlled Trials Register (Cochrane Library Issue 1, 2002), MEDLINE (January 1966 to July 2002), EMBASE (January 1988 to July 2002), SCIENCE Direct Database (January 1966 to July 2002), Confsci (January 1973 to 15 July 2002), Pascal (January 1984 to July 2002) and reference lists of articles. We also contacted researchers in the field.
Randomised controlled, parallel trials of single versus double intrauterine inseminations in simulated cycles in subfertile couples.
Two reviewers independently assessed trial quality and extracted data. Study authors were contacted for additional information.
Three studies involving 386 women were included. There was no data for the main outcome measure of live birth per couple or ongoing pregnancy rates, and none presented comparative data for adverse events. The results of two studies that reported pregnancy rate per couple did not show a significant effect of using double insemination (Peto OR 1.45, 95% CI 0.78-2.70).
REVIEWER'S CONCLUSIONS: Based on the results of pregnancy rate per couple of two trials, double intrauterine insemination showed no significant benefit over single intrauterine insemination in the treatment of subfertile couples with husband semen. There are no meaningful data to offer advice regarding clinical practice on the basis of this review.
宫腔内人工授精（IUI），无论是否联合控制性卵巢过度刺激（COH），都是为尝试受孕至少一年的夫妇（亚生育夫妇）提供的治疗方式之一。有人提出，将每个周期的授精次数从一次增加到两次可能会提高受孕几率。
确定在刺激周期中，亚生育夫妇使用单次或双次宫腔内人工授精的活产率或妊娠率是否存在差异。
我们检索了Cochrane月经紊乱与亚生育组试验注册库（检索日期为2002年7月8日）、Cochrane对照试验注册库（Cochrane图书馆2002年第1期）、MEDLINE（1966年1月至2002年7月）、EMBASE（1988年1月至2002年7月）、SCIENCE Direct数据库（1966年1月至2002年7月）、Confsci（1973年1月至2002年7月15日）、Pascal（1984年1月至2002年7月）以及文章的参考文献列表。我们还联系了该领域的研究人员。
亚生育夫妇在模拟周期中进行单次与双次宫腔内人工授精的随机对照平行试验。
两名评价员独立评估试验质量并提取数据。与研究作者联系以获取更多信息。
纳入了三项涉及386名女性的研究。没有关于每对夫妇活产或持续妊娠率这一主要结局指标的数据，也没有研究呈现不良事件的比较数据。两项报告了每对夫妇妊娠率的研究结果未显示双次授精有显著效果（Peto比值比1.45，95%可信区间0.78 - 2.70）。
基于两项试验中每对夫妇妊娠率的结果，在治疗丈夫精液异常的亚生育夫妇时，双次宫腔内人工授精相较于单次宫腔内人工授精未显示出显著益处。基于本综述，没有有意义的数据可用于指导临床实践。
