Nicholson R, Small J, Dixon A K, Spanswick D, Lee K
Pfizer Global Research and Development, Cambridge University Forvie Site, Robinson Way, CB2 2QB, Cambridge, UK.
Neurosci Lett. 2003 Feb 13;337(3):119-22. doi: 10.1016/s0304-3940(02)01256-9.
In the present study, we have used in situ hybridization to examine the distribution of serotonin (5-HT) receptors in rat dorsal root ganglion (DRG) neurons. Within DRG neurons, mRNAs for 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT3B and 5-HT4 receptors were readily detected in small (<25 microm), medium (25-45 microm) and large (>45 microm) diameter neurons. In contrast mRNAs for 5-HT1A, 5-HT1E, 5-HT2C, 5-HT5A, 5-HT5B, 5-HT6 and 5-HT7 receptors were undetectable in these neurons. The present study provides an insight into the molecular profile of 5-HT receptor subtypes in neurons responsible for modulating sensory information.
在本研究中，我们使用原位杂交技术检测了大鼠背根神经节（DRG）神经元中5-羟色胺（5-HT）受体的分布。在DRG神经元内，5-HT1B、5-HT1D、5-HT2A、5-HT2B、5-HT3B和5-HT4受体的信使核糖核酸（mRNA）在直径小（<25微米）、中（25 - 45微米）和大（>45微米）的神经元中很容易被检测到。相比之下，5-HT1A、5-HT1E、5-HT2C、5-HT5A、5-HT5B、5-HT6和5-HT7受体的mRNA在这些神经元中未被检测到。本研究为负责调节感觉信息的神经元中5-HT受体亚型的分子概况提供了深入了解。
