Freiesleben H, Sack K
Chemotherapy. 1976;22(2):75-83. doi: 10.1159/000221915.
Therapy of chronic E. coli pyelonephritis in rats was equally effective with cyclacillin and oral ampicillin, whereas intramuscular ampicillin had a significantly higher therapeutic activity than oral cyclacillin. Serum concentrations in rats and mice were consistently higher with cyclacillin than with ampicillin and showed great variations depending on the animal species. It was concluded that there is a good correlation between in vivo and in vitro activity of both antibiotics, provided that the serum levels are taken into consideration. On this basis it may be predicted that a man cyclacillin will exhibit lower therapeutic activity in gram-negative infections than ampicillin.
在大鼠慢性大肠杆菌肾盂肾炎的治疗中，环青霉素与口服氨苄西林疗效相当，而肌肉注射氨苄西林的治疗活性明显高于口服环青霉素。环青霉素在大鼠和小鼠体内的血清浓度始终高于氨苄西林，且因动物种类不同而有很大差异。得出的结论是，只要考虑血清水平，这两种抗生素的体内和体外活性之间有良好的相关性。在此基础上可以预测，在革兰氏阴性菌感染中，人用环青霉素的治疗活性将低于氨苄西林。
