口服环己西林和氨苄西林的双盲临床试验。
Double-blind clinical trials of oral cyclacillin and ampicillin.
作者信息
Gold J A, Hegarty C P, Deitch M W, Walker B R
出版信息
Antimicrob Agents Chemother. 1979 Jan;15(1):55-8. doi: 10.1128/AAC.15.1.55.
Abstract
A double-blind study was performed to compare the clinical response and the incidence of side effects in 2,581 patients administered ampicillin or cyclacillin for infections of the genitourinary or respiratory tract, infections of the skin and soft tissues, or for otitis media. There was no significant difference in clinical response and bacterial eradication. All side effects, including diarrhea and skin rash, were approximately twice as frequent in patients treated with ampicillin.
摘要
进行了一项双盲研究，以比较2581例因泌尿生殖道或呼吸道感染、皮肤和软组织感染或中耳炎而接受氨苄西林或环青霉素治疗的患者的临床反应和副作用发生率。临床反应和细菌清除率无显著差异。包括腹泻和皮疹在内的所有副作用在接受氨苄西林治疗的患者中出现的频率约为前者的两倍。
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