Zhou Z, Chen Z, Yang P, Shu Y, Zhang Z, Gao X, Chen H
Department of General Surgery & Experimental Centre of Microcirculation, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Hua Xi Yi Ke Da Xue Xue Bao. 2001 Sep;32(3):330-4, 371.
This study sought to gain an insight into the blood drainage of Langerhans islets with special reference to the functional and clinical significance of pancreatic exocrine part.
Observations were carried out in 11 human dead bodies, 40 monkeys, 24 dogs, 62 rats and 24 rabbits by scanning electron microscopy and light microscopy with the technique of retaining microcirculatory dynamic and tissular information in the static specimens, microvascular serial reconstruction, and/or by intravital fluorecence microscopy with FITC-labeled erythrocytes.
Three patterns of islet drainage channels drained into different acinar regions with different features and insulo-insular drainage channels observed in the primates were found in this study. The authors suggest that these patterns might be termed as follows: 1. Continuous drainage vessels. All islets possessed these capillary-sized portal vessels which ran a short distance, and then drained into the peri-islet acinar region. 2. Convergent drainage vessels. Some islets possessed one or two, occasionally more, of these portal vessels, which were relatively long and/or thick and drained into the acinar region far away from the islet in the lobule. 3. Translobular drainage vessels. These portal vessels crossed the interlobular septum into an adjacent lobule where sometimes no islet existed, and then drained into the exocrine acinar region 4. Insulo-insular drainage vessels. Some islets in the monkey and human, possessed these vessels which drained into an adjacent small islet through the insulo-insular drainage vessels.
Langerhans islets possessed the consummate drainage system which drained into different exocrine acinar regions, suggesting that the release of islet hormones is in some way necessary for the exocrine secreting function, and that the reduction of local insular hormone levels in insuloacinar portal circulation and the impairment of insular drainage vessels would be the morphological basis of the pancreatic exocrine pathologic lesion in human diabetes.
本研究旨在深入了解朗格汉斯胰岛的血液引流情况，特别关注胰腺外分泌部的功能和临床意义。
通过扫描电子显微镜和光学显微镜，采用在静态标本中保留微循环动态和组织信息的技术、微血管序列重建，和/或使用异硫氰酸荧光素标记红细胞的活体荧光显微镜，对11具人类尸体、40只猴子、24只狗、62只大鼠和24只兔子进行观察。
本研究发现了三种胰岛引流通道模式，它们排入不同的腺泡区域，具有不同特征，并且在灵长类动物中观察到了胰岛间引流通道。作者建议这些模式可如下命名：1. 连续引流血管。所有胰岛都拥有这些毛细血管大小的门静脉血管，它们走行较短距离，然后排入胰岛周围的腺泡区域。2. 汇聚引流血管。一些胰岛拥有一两条，偶尔更多，这些门静脉血管，它们相对较长和/或较粗，排入小叶中远离胰岛的腺泡区域。3. 跨小叶引流血管。这些门静脉血管穿过小叶间隔进入相邻小叶，有时该小叶不存在胰岛，然后排入外分泌腺泡区域。4. 胰岛间引流血管。猴子和人类的一些胰岛拥有这些血管，它们通过胰岛间引流血管排入相邻的小胰岛。
朗格汉斯胰岛拥有完善的引流系统，排入不同的外分泌腺泡区域，这表明胰岛激素的释放对外分泌分泌功能在某种程度上是必要的，并且胰岛腺泡门静脉循环中局部胰岛激素水平的降低和胰岛引流血管的损害将是人类糖尿病胰腺外分泌病理病变的形态学基础。
