Kyrtsonis Marie-Christine, Vassilakopoulos Theodoros P, Kafasi Nicoletta, Sachanas Sotirios, Tzenou Tatiana, Papadogiannis Argiroula, Galanis Zacharoula, Kalpadakis Christina, Dimou Maria, Kyriakou Elias, Angelopoulou Maria K, Dimopoulou Maria N, Siakantaris Marina P, Dimitriadou Evangelia M, Kokoris Styliani I, Panayiotidis Panayiotis, Pangalis Gerassimos A
Department of Haematology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
Br J Haematol. 2007 May;137(3):240-3. doi: 10.1111/j.1365-2141.2007.06561.x.
The prognostic value of baseline serum free light chain ratio (sFLCR) was investigated in 94 multiple myeloma (MM) patients. sFLCR was calculated as kappa/lambda or lambda/kappa, depending on the patients' dominating monoclonal light chain. Median baseline sFLCR was 3.57 in kappa-MM patients, 45.09 in lambda-MM. 'High' sFLCR (> or = the observed median value for kappa- and lambda-MM respectively) correlated with elevated serum creatinine and lactate dehydrogenase, extensive marrow infiltration and light chain type MM. The 5-year disease-specific survival was 82% and 30% in patients with sFLCR lower than and equal or greater than the median, respectively (P = 0.0001). sFLCR was an independent prognostic factor.
对94例多发性骨髓瘤（MM）患者的基线血清游离轻链比值（sFLCR）的预后价值进行了研究。根据患者占主导地位的单克隆轻链，sFLCR计算为κ/λ或λ/κ。κ型MM患者的基线sFLCR中位数为3.57，λ型MM患者为45.09。“高”sFLCR（分别>或=κ型和λ型MM观察到的中位数）与血清肌酐和乳酸脱氢酶升高、广泛的骨髓浸润以及轻链型MM相关。sFLCR低于中位数和等于或高于中位数的患者5年疾病特异性生存率分别为82%和30%（P = 0.0001）。sFLCR是一个独立的预后因素。
