Chen X, Liu H, Ma Z H
Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Hunan Yi Ke Da Xue Xue Bao. 2001 Aug 28;26(4):374-6.
To compare the diuretic effect of coadministration of dextran and flurosemide with that of coadministration of Albumin and flurosemide on primary nephrotic syndrome.
In a double-blind placebo-controlled study, eighteen primary nephrotic syndrome patients on standard sodium chloride intake, random by divided into three groups and received by intravenous administration for 60 minutes for three days (a) FU (1 mg.kg-1) combination with a sham infusion, (b) FU (1 mg.kg-1) combination with 50 ml of 20% solution of Albumin, or (c) FU (1 mg/kg) combination with 250 ml dextran 40. Urinary volume, sodium and plasma atrial nartiuretic peptide concentration were assessed.
The results showed that administration of FU alone increased mean cumulative urinary sodium and volume excretion as compared with the administration of sham infusion without treatment (P < 0.05). The administration of FU and albumin or FU and dextran 40 caused an even more marked increase of urinary sodium and volume excretion (P < 0.01), as compared with the administration of sham infusion without treatment. Plasma ANP increased significantly on both albumin infusion days and dextran 40 infusion days (P < 0.05).
Coadministration of albumin and FU or dextran 40 and FU can increase the urinary volume and urinary Na and ANP significantly, dextran 40 can take the place of albumin because there was no difference between the administration of FU and albumin and FU and dextran in UV, Una and ANP.
比较右旋糖酐与呋塞米联合应用和白蛋白与呋塞米联合应用对原发性肾病综合征的利尿效果。
在一项双盲安慰剂对照研究中，18例原发性肾病综合征患者维持标准氯化钠摄入量，随机分为三组，静脉输注60分钟，共3天：(a) 呋塞米（1 mg·kg-1）联合假输液；(b) 呋塞米（1 mg·kg-1）联合50 ml 20%白蛋白溶液；(c) 呋塞米（1 mg/kg）联合250 ml右旋糖酐40。评估尿量、钠及血浆心钠素浓度。
结果显示，与未治疗的假输液相比，单独使用呋塞米可增加平均累积尿钠和尿量排泄（P<0.05）。与未治疗的假输液相比，呋塞米与白蛋白或呋塞米与右旋糖酐40联合应用可使尿钠和尿量排泄更显著增加（P<0.01）。在输注白蛋白和输注右旋糖酐40的日子里，血浆心钠素均显著升高（P<0.05）。
白蛋白与呋塞米或右旋糖酐40与呋塞米联合应用可显著增加尿量、尿钠及心钠素，右旋糖酐40可替代白蛋白，因为在尿量、尿钠及心钠素方面，呋塞米与白蛋白联合应用和呋塞米与右旋糖酐联合应用之间无差异。
