Rego Filho E de A, Casoni W
Rev Bras Pesqui Med Biol. 1977;10(5):299-304.
The authors have studied the effect of the infusion of sodium poor albumin on the primary nephrotic syndrome edema in children. The albumin dose used was 1 g per kilo, administered intravenously during four hours. A variable weight loss of 5.7% to 8.3% related to the initial weight was observed. The urinary volume increased considerably during the study period, as well as the urinary sodium excretion and creatinine clearance. The study of the relation of the urinary Na/K suggests that the secondary hyperaldosteronism is blocked by the albumin infusion probably due to an increase in the intravascular volume. They have concluded that the administration of sodium poor albumin whether or not associated to diuretics is effective in controlling the Primary Nephrotic Syndrome edema in children.
作者们研究了输注低钠白蛋白对儿童原发性肾病综合征水肿的影响。所用白蛋白剂量为每公斤1克，在4小时内静脉给药。观察到体重较初始体重有5.7%至8.3%的可变减轻。在研究期间，尿量显著增加，尿钠排泄和肌酐清除率也增加。对尿钠/钾关系的研究表明，输注白蛋白可能由于血管内容量增加而阻断了继发性醛固酮增多症。他们得出结论，无论是否与利尿剂联合使用，输注低钠白蛋白对控制儿童原发性肾病综合征水肿均有效。
