Tian Z, Wang Y, Zhang W
Department of Oral Pathology, School of Stomatology, Shanghai Second Medical University.
Hua Xi Kou Qiang Yi Xue Za Zhi. 1999 Aug;17(3):236-8, 253.
To investigate the expression of the basement membrane proteins in adenoid cystic carcinoma (ACC) of the salivary glands and discuss the relationship between the expression of the proteins and the differentiation as well the prognosis of ACC.
101 patients which were confirmed pathologically were collected and made a follow-up, and 30 cases of them were selected to detect the basement membrane proteins (type IV collagen, fibronectin, laminin and heparan sulfate proteoglycan) by the means of immunohistochemistry.
The cribriform pattern of ACC had a more favorable prognosis than the solid pattern which had a lower rates of metastasis of/and recurrence. The positive locations and the degrees of the four proteins varied with the histological patterns of ACC. The cribriform pattern had the strongest positive expression and the solid pattern the weakest. In addition, the staining of fibronectin were weaker in all three patterns of ACC.
The degree of the positive expression of the four proteins has a negative relation to the differentiation of the tumor cells. The lower degree of differentiation the tumor cells are, the weaker positive signals they express. Of the four substances in the basement membrane, laminin is the main material which adhere the parenchymal cell to the collagen in basement membrane of the tumor. Basement membrane proteins could be regarded as one of the basis to evaluate the prognosis of ACC.
研究涎腺腺样囊性癌（ACC）中基底膜蛋白的表达情况，探讨其表达与ACC分化程度及预后的关系。
收集101例经病理确诊的患者并进行随访，从中选取30例采用免疫组织化学方法检测基底膜蛋白（IV型胶原、纤连蛋白、层粘连蛋白和硫酸乙酰肝素蛋白聚糖）。
ACC筛状型的预后优于实体型，实体型的转移率和复发率较低。四种蛋白的阳性定位和程度随ACC的组织学类型而异。筛状型阳性表达最强，实体型最弱。此外，在ACC的所有三种类型中纤连蛋白的染色均较弱。
四种蛋白的阳性表达程度与肿瘤细胞的分化呈负相关。肿瘤细胞分化程度越低，其表达的阳性信号越弱。在基底膜的四种物质中，层粘连蛋白是肿瘤基底膜中使实质细胞黏附于胶原的主要物质。基底膜蛋白可作为评估ACC预后的依据之一。
