细胞内牛分枝杆菌卡介苗对J774.1巨噬细胞L-精氨酸代谢的调节
Modulation of J774.1 macrophage L-arginine metabolism by intracellular Mycobacterium bovis BCG.
作者信息
Peteroy-Kelly Marcy A, Venketaraman Vishwanath, Talaue Meliza, Seth Anjali, Connell Nancy D
机构信息
Department of Microbiology and Molecular Genetics, International Center for Public Health, UMDNJ/New Jersey Medical School, Newark 07101-1709, USA.
出版信息
Infect Immun. 2003 Feb;71(2):1011-5. doi: 10.1128/IAI.71.2.1011-1015.2003.
Abstract
Using a Mycobacterium bovis BCG mutant (AS1) lacking a Bacillus subtilis L-arginine transporter homolog, we demonstrate here that the interaction between intracellular mycobacteria and the macrophage with respect to L-arginine transport and metabolism is quite complex. Intracellular AS1 stimulates macrophage L-arginine transport and accumulates 2.5-fold more (3)H label derived from L-arginine than does the wild type. These studies suggest that the accumulation of (3)H label reflects the acquisition of metabolites of L-arginine produced by the macrophage.
摘要
使用一种缺乏枯草芽孢杆菌L-精氨酸转运蛋白同源物的牛分枝杆菌卡介苗突变体（AS1），我们在此证明，细胞内分枝杆菌与巨噬细胞在L-精氨酸转运和代谢方面的相互作用相当复杂。细胞内的AS1刺激巨噬细胞的L-精氨酸转运，并且从L-精氨酸衍生的（3）H标记积累量比野生型多2.5倍。这些研究表明，（3）H标记的积累反映了巨噬细胞产生的L-精氨酸代谢产物的获取。
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