雅登诺酮A和B：源自印度洋海绵近似比氏斧海绵的新型细胞毒性三萜类化合物。

Yardenone A and B: new cytotoxic triterpenes from the Indian Ocean sponge Axinella cf. bidderi.

作者信息

Carletti Isabelle, Long Christophe, Funel Corinne, Amade Philippe

机构信息

Laboratoire de Chimie Bioorganique, UMR-CNRS 6001, UNSA, Parc Valrose, 06108 Nice Cedex 02, France.

出版信息

J Nat Prod. 2003 Jan;66(1):25-9. doi: 10.1021/np020208t.

DOI:10.1021/np020208t

PMID:12542339

Abstract

Two new polyepoxysqualene-derived triterpenes, yardenone A (1) and B (2), together with the known yardenone (3) and sodwanone A (4), have been isolated from the marine sponge Axinella cf. bidderi from Yemen's Socotra Island in the Indian Ocean. The structures were elucidated using spectroscopic data. The relative stereochemistry was established by the analysis of ROESY spectra as well as coupling constants and molecular modeling. Furthermore, the absolute configuration of 1 was confirmed by the advanced Mosher's method. The cytotoxicity of these compounds was evaluated against a NSCLC cell line.

摘要

从印度洋也门索科特拉岛的一种海绵（近似比氏斧海绵）中分离出了两种新的聚环氧角鲨烯衍生三萜类化合物，即雅登酮A（1）和B（2），以及已知的雅登酮（3）和索德瓦酮A（4）。通过光谱数据阐明了其结构。通过ROESY光谱分析以及耦合常数和分子建模确定了相对立体化学。此外，通过先进的莫舍尔方法确定了1的绝对构型。评估了这些化合物对一种非小细胞肺癌细胞系的细胞毒性。