来自薄星骨海绵的细胞毒性异马拉巴烷型三萜类化合物——星骨海绵素L和M以及甾醇。

Stellettins L and M, cytotoxic isomalabaricane-type triterpenes, and sterols from the marine sponge Stelletta tenuis.

作者信息

Lin Hou-wen, Wang Zeng-lei, Wu Jiu-hong, Shi Ning, Zhang Hong-jun, Chen Wan-sheng, Morris-Natschke Susan L, Lin An-Shen

机构信息

Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Fengyang Road 415, Shanghai 200003, People's Republic of China.

出版信息

J Nat Prod. 2007 Jul;70(7):1114-7. doi: 10.1021/np070069l. Epub 2007 Jun 30.

DOI:10.1021/np070069l

PMID:17604394

Abstract

Two new isomalabaricane-type triterpenes, stellettins L (1) and M (2), and three new sterols (3-5) were isolated from the marine sponge Stelletta tenuis collected in the South China Sea. Chemical structures were established from spectroscopic data and comparison with known compounds. In addition, spectroscopic data reported for the known sterol 24-methylene-27-methylcholest-5-en-3beta-ol-7-one (6) were revised. Compounds 1 and 2 exhibited significant cytotoxic activity against stomach cancer (AGS) in vitro.

摘要

从中国南海采集的细薄星芒海绵（Stelletta tenuis）中分离得到了两种新的异葫芦素烷型三萜——星芒海绵素L（1）和M（2），以及三种新的甾醇（3 - 5）。通过光谱数据并与已知化合物进行比较确定了化学结构。此外，对已知甾醇24-亚甲基-27-甲基胆甾-5-烯-3β-醇-7-酮（6）报道的光谱数据进行了修正。化合物1和2在体外对胃癌（AGS）表现出显著的细胞毒性活性。