球星海绵酸A-D，来自海洋海绵球星海绵的新型具有细胞毒性的异马拉巴烷三萜。
Globostellatic acids A-D, new cytotoxic isomalabaricane triterpenes from the marine sponge Stelletta globostellata.
作者信息
Ryu G, Matsunaga S, Fusetani N
机构信息
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan.
出版信息
J Nat Prod. 1996 May;59(5):512-4. doi: 10.1021/np9601317.
PMID:8778241
Abstract
Four new cytotoxic triterpenes, globostellatic acids A-D (1-4), have been isolated from the marine sponge Stelletta globostellata. Their structures have been determined by interpretation of spectral data. They exhibited cytotoxicity against P-388 murine leukemia cells with IC50 values of 0.1-0.46 microgram/mL.
摘要
从海洋海绵球星海绵（Stelletta globostellata）中分离出了四种新的细胞毒性三萜类化合物，球星海绵酸A-D（1-4）。通过光谱数据解析确定了它们的结构。它们对P-388小鼠白血病细胞表现出细胞毒性，IC50值为0.1-0.46微克/毫升。
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