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阿奇霉素用于沙眼的社区治疗在1年内与肺炎链球菌的抗生素耐药性无关。

Community treatment with azithromycin for trachoma is not associated with antibiotic resistance in Streptococcus pneumoniae at 1 year.

作者信息

Gaynor B D, Holbrook K A, Whitcher J P, Holm S O, Jha H C, Chaudhary J S P, Bhatta R C, Lietman T

机构信息

The Francis I Proctor Foundation and the Department of Ophthalmology, University of California, San Francisco, 94143, USA.

出版信息

Br J Ophthalmol. 2003 Feb;87(2):147-8. doi: 10.1136/bjo.87.2.147.

DOI:10.1136/bjo.87.2.147
PMID:12543738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1771508/
Abstract

AIMS

To determine if macrolide resistant Streptococcus pneumoniae will be a major concern in areas that receive annual mass azithromycin distributions for trachoma.

METHODS

A cross sectional survey was conducted of nasopharyngeal S pneumoniae isolates for susceptibility to azithromycin 1 year after administering a single dose of azithromycin to treat trachoma in a village in Nepal.

RESULTS

S pneumoniae was isolated from 50 (86%) of 57 nasopharyngeal cultures and no resistance to azithromycin was detected.

CONCLUSION

The authors were unable to demonstrate that mass azithromycin therapy for trachoma produced macrolide resistant S pneumoniae that persists until the next scheduled annual treatment.

摘要

目的

确定在每年接受大规模阿奇霉素用于治疗沙眼的地区，对大环内酯类耐药的肺炎链球菌是否会成为一个主要问题。

方法

在尼泊尔一个村庄对单剂量阿奇霉素治疗沙眼1年后的鼻咽部肺炎链球菌分离株进行阿奇霉素敏感性横断面调查。

结果

从57份鼻咽部培养物中的50份（86%）分离出肺炎链球菌，未检测到对阿奇霉素的耐药性。

结论

作者未能证明大规模阿奇霉素治疗沙眼会产生持续至下一次预定年度治疗的大环内酯类耐药肺炎链球菌。

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本文引用的文献

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Comparison of two azithromycin distribution strategies for controlling trachoma in Nepal.尼泊尔两种阿奇霉素分发策略用于控制沙眼的比较。
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A targeted, single-dose azithromycin strategy for trachoma.
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Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in the United States, 1997-1998.1997 - 1998年美国分离出的肺炎链球菌、流感嗜血杆菌和卡他莫拉菌的耐药性监测
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Alterations in the conjunctival bacterial flora following a single dose of azithromycin in a trachoma endemic area.在沙眼流行地区单次服用阿奇霉素后结膜细菌菌群的变化
Br J Ophthalmol. 1999 Dec;83(12):1332-5. doi: 10.1136/bjo.83.12.1332.
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Patterns of macrolide resistance determinants among community-acquired Streptococcus pneumoniae isolates over a 5-year period of decreased macrolide susceptibility rates.在大环内酯类药物敏感性降低率的5年期间，社区获得性肺炎链球菌分离株中大环内酯类耐药决定因素的模式。
Antimicrob Agents Chemother. 1999 Oct;43(10):2510-2. doi: 10.1128/AAC.43.10.2510.
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Azithromycin in control of trachoma.阿奇霉素用于控制沙眼
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Global elimination of trachoma: how frequently should we administer mass chemotherapy?全球消除沙眼：我们应多久进行一次大规模化疗？
Nat Med. 1999 May;5(5):572-6. doi: 10.1038/8451.
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Prevalence of antimicrobial resistance among respiratory tract isolates of Streptococcus pneumoniae in North America: 1997 results from the SENTRY antimicrobial surveillance program.北美肺炎链球菌呼吸道分离株的抗菌药物耐药性流行情况：1997年哨兵抗菌药物监测项目的结果
Clin Infect Dis. 1998 Oct;27(4):764-70. doi: 10.1086/514953.
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The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland. Finnish Study Group for Antimicrobial Resistance.芬兰大环内酯类抗生素消费变化对A组链球菌红霉素耐药性的影响。芬兰抗菌药物耐药性研究小组。
N Engl J Med. 1997 Aug 14;337(7):441-6. doi: 10.1056/NEJM199708143370701.
10
A comparison of oral azithromycin with topical oxytetracycline/polymyxin for the treatment of trachoma in children.口服阿奇霉素与外用土霉素/多粘菌素治疗儿童沙眼的比较。
Clin Infect Dis. 1997 Mar;24(3):363-8. doi: 10.1093/clinids/24.3.363.