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Recombinant human activated protein C in sepsis: inconsistent trial results, an unclear mechanism of action, and safety concerns resulted in labeling restrictions and the need for phase IV trials.

作者信息

Eichacker Peter Q, Natanson Charles

机构信息

Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Crit Care Med. 2003 Jan;31(1 Suppl):S94-6. doi: 10.1097/00003246-200301001-00013.

DOI:10.1097/00003246-200301001-00013
PMID:12544982
Abstract
摘要

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Recombinant human activated protein C in sepsis: inconsistent trial results, an unclear mechanism of action, and safety concerns resulted in labeling restrictions and the need for phase IV trials.重组人活化蛋白C用于脓毒症治疗:试验结果不一致、作用机制不明以及安全性问题导致了标签限制和开展IV期试验的必要性。
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Recombinant human activated protein C for severe sepsis in neonates.重组人活化蛋白C用于新生儿严重脓毒症
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Results from the National Sepsis Practice Survey: use of drotrecogin α (activated) and other therapeutic decisions.国家脓毒症实践调查结果:使用替考拉宁 α(激活)和其他治疗决策。
J Crit Care. 2010 Dec;25(4):658.e7-15. doi: 10.1016/j.jcrc.2010.04.010. Epub 2010 Jun 19.
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Clin Microbiol Infect. 2009 Apr;15(4):308-18. doi: 10.1111/j.1469-0691.2009.02752.x.
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Intensive Care Med. 2008 Nov;34(11):1950-4. doi: 10.1007/s00134-008-1302-6. Epub 2008 Oct 7.
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