Ding G F
Department of Immunology, Peking University Health Science Center, Beijing 100083.
Sheng Li Ke Xue Jin Zhan. 2001 Jul;32(3):233-9.
The initiators of intestinal inflammation are greatly variable, but the mechanisms underlying the immunologically mediated mucosal damage are similar. A great progress in our understanding of the functions of gut-associated lymphoid tissue was achieved because of the advances in immuno-biology and molecular immunology. At the beginning of an inflammation microorganisms and hither to derived products or allergen firstly stimulate and activate the specific and nonspecific immune cells, and then intestine epithelials, macrophages and lymphocytes release various cytokines. These cytokines are able to recruit more immune cells to be activated and more cytokines to be released. A "cascade" is then generated between epithelials, macrophages and lymphocytes. Finally the inflammation in certain area of intestinal tract is generated. The balance between inflammatory factors and anti-inflammatory molecules depends the results of the inflammation. Therefore, the better understanding of the mechanisms on inflammatory and anti-inflammatory factors is helpful for the diagnosis and treatment of intestinal inflammation.
肠道炎症的引发因素差异很大，但免疫介导的黏膜损伤的潜在机制相似。由于免疫生物学和分子免疫学的进展，我们对肠道相关淋巴组织功能的理解取得了巨大进步。在炎症开始时，微生物及其衍生产物或过敏原首先刺激并激活特异性和非特异性免疫细胞，然后肠道上皮细胞、巨噬细胞和淋巴细胞释放各种细胞因子。这些细胞因子能够招募更多免疫细胞被激活并释放更多细胞因子。然后在上皮细胞、巨噬细胞和淋巴细胞之间产生一个“级联反应”。最后在肠道的特定区域产生炎症。炎症因子和抗炎分子之间的平衡决定了炎症的结果。因此，更好地了解炎症和抗炎因子的机制有助于肠道炎症的诊断和治疗。
