Nikolaeva T N, Zorina V V, Bondarenko V M
Eksp Klin Gastroenterol. 2004(4):39-43, 109.
One of major functions of lactic acid bacteria is their participation in the formation of local and systemic immune resistance of the host. The lactic acid bacteria associated with the mucous coat of the gastro-intestinal tract are cooperating with epitheliocytes, M-cells of Peyer's patches and various cells of the immune system. As a result of processing and presentation of specific cell components, lactic acid bacteria use mechanisms of modulation of cell-dependent immune response, activate RES and stimulate cytokine production. The article gives data on the role of lactic acid bacteria in the formation of T-and B-cell immune response, production of pro-inflammatory and anti-inflammatory cytokines ensuring the balance between humoral and cell-dependent immunity. The mechanisms of antitumor and oncostatic activity of lactic acid bacteria are analyzed. The polyfunctional influence of lactic acid bacteria on the immune reactions of the macroorganism includes the enhancement of the activity of monocyto-macrophages, natural killers and cytotoxic lymphocytes, modulation of reactions of the T- and B-cell immune responses, i.e. the complex system of interaction being formed between the indigenous intestinal microflora and the macroorganism is the basis of the normal function of its immune system.
乳酸菌的主要功能之一是参与宿主局部和全身免疫抵抗力的形成。与胃肠道黏液层相关的乳酸菌与上皮细胞、派尔集合淋巴结的M细胞以及免疫系统的各种细胞相互协作。通过对特定细胞成分的加工和呈递，乳酸菌利用细胞依赖性免疫反应的调节机制，激活网状内皮系统（RES）并刺激细胞因子的产生。本文给出了关于乳酸菌在T细胞和B细胞免疫反应形成中所起作用的数据，以及其在产生促炎和抗炎细胞因子以确保体液免疫和细胞依赖性免疫之间平衡方面的作用。分析了乳酸菌的抗肿瘤和抑癌活性机制。乳酸菌对机体免疫反应的多方面影响包括增强单核细胞 - 巨噬细胞、自然杀伤细胞和细胞毒性淋巴细胞的活性，调节T细胞和B细胞免疫反应，即肠道固有微生物群与机体之间形成的复杂相互作用系统是其免疫系统正常功能的基础。
