Lloyd F, Gilman E A, Law G R, Cartwright R A
York District General Hospital, York Y031 8HE.
J Public Health Med. 2002 Dec;24(4):255-60. doi: 10.1093/pubmed/24.4.255.
The aim of the study was to independently test the hypothesis that leukaemia incidence is higher in proximity to estuaries.
Electoral wards were classified as to whether they included estuarine, coastal or only inland features. Rates of different adult and childhood leukaemias were computed for each ward category; that is, acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML) aged 0-79 and for all childhood leukaemias combined (aged 0-14).
Poisson regression analysis controlling for the effects of sex, age, and socioeconomic and urban-rural status, showed no statistically significant differences in incidence between wards with different levels of estuarine classification.
The hypothesis created from an earlier dataset that a link exists between leukaemia and residence near estuaries is not upheld.
本研究的目的是独立检验白血病发病率在河口附近更高这一假设。
选区根据其是否包含河口、沿海或仅内陆特征进行分类。计算每个选区类别中不同成人和儿童白血病的发病率；即0至79岁的急性淋巴细胞白血病（ALL）、急性髓细胞白血病（AML）、慢性髓细胞白血病（CML）以及所有儿童白血病合并（0至14岁）。
在控制了性别、年龄、社会经济和城乡地位影响的泊松回归分析中，不同河口分类水平的选区之间发病率没有统计学上的显著差异。
从早期数据集得出的白血病与居住在河口附近之间存在联系的假设未得到支持。
