Alexander F E, Ricketts T J, McKinney P A, Cartwright R A
Department of Pathology, University of Leeds, UK.
Lancet. 1990 Dec 15;336(8729):1461-5. doi: 10.1016/0140-6736(90)93176-p.
High rates of leukaemia in children and young people have been associated with features of community isolation and population growth. Incidence data collected by two specialist registries were used to compare incidence rates at ward level with relevant ward characteristics derived from routine census and Ordnance Survey data for England and Wales. An excess risk of childhood acute lymphoblastic leukaemia (ALL) was found for wards which are farthest from large urban centres. The excess was greatest for wards of higher socioeconomic status and for children aged 1-7 years (the childhood peak), for which a two-fold excess was seen. These findings in general support the hypothesis that childhood leukaemia has an infectious aetiology.
儿童和年轻人白血病的高发病率与社区隔离和人口增长特征有关。两个专业登记处收集的发病率数据被用于将病房层面的发病率与从英格兰和威尔士的常规人口普查及地形测量数据得出的相关病房特征进行比较。在距离大型城市中心最远的病房中发现儿童急性淋巴细胞白血病（ALL）存在超额风险。对于社会经济地位较高的病房以及1至7岁的儿童（儿童发病高峰），超额风险最大，观察到其超额风险为两倍。总体而言，这些发现支持了儿童白血病具有感染病因这一假说。
