Walker W S
J Immunol. 1976 Apr;116(4):911-4.
The specificity of Fe-receptors on IC-21 cells, an established line of mouse peritoneal macrophages with antibody-dependent effector cell activity has been examined. Only IgG2a and IgG2b myeloma proteins bound readily to IC-21 Fc-receptors, the former in nonaggregated as well as aggregated form, the latter only as aggregated complexes. Thus, IgG2a bound in a manner characteristic of classically defined cytophilic antibody, whereas the binding of IgG2b appeared to be mediated by Fc-receptors for antigen-antibody complexes. Evidence is presented in support of the view that IC-21 macrophages possess separate and distinct Fc-receptor sites for these two immunoglobulins.
已对IC-21细胞（一种具有抗体依赖性效应细胞活性的成熟小鼠腹膜巨噬细胞系）上铁受体的特异性进行了研究。只有IgG2a和IgG2b骨髓瘤蛋白能轻易结合到IC-21 Fc受体上，前者以非聚集形式和聚集形式均可结合，后者仅以聚集复合物形式结合。因此，IgG2a以经典定义的嗜细胞抗体的特征方式结合，而IgG2b的结合似乎是由抗原-抗体复合物的Fc受体介导的。有证据支持这样一种观点，即IC-21巨噬细胞对这两种免疫球蛋白具有独立且不同的Fc受体位点。
