可溶性免疫复合物对巨噬细胞Fc受体和C3b受体介导的吞噬作用的影响。
Effects of soluble immune complexes on Fc receptor- and C3b receptor-mediated phagocytosis by macrophages.
作者信息
Griffin F M
出版信息
J Exp Med. 1980 Oct 1;152(4):905-19. doi: 10.1084/jem.152.4.905.
Abstract
The effects of ingestion of soluble immune complexes upon macrophage phagocytic function was studied. Ingestion of immune complexes severely impaired the macrophage's ability to ingest IgG-coated particles but did not alter its ability to interact with particles by means other than its Fc receptors. Treatment of macrophages that had ingested immune complexes with supernates containing the previously described lymphokine that augments macrophage complement receptor function failed to enhance the cells' interaction with either IgG-coated erythrocytes or zymosan particles but markedly enhanced their ability to phagocytize via their complement receptors. The possible significance of these findings in immunologically mediated inflammation is discussed.
摘要
研究了摄入可溶性免疫复合物对巨噬细胞吞噬功能的影响。摄入免疫复合物严重损害了巨噬细胞摄取IgG包被颗粒的能力，但并未改变其通过Fc受体以外的方式与颗粒相互作用的能力。用含有上述增强巨噬细胞补体受体功能的淋巴因子的上清液处理已摄入免疫复合物的巨噬细胞，未能增强细胞与IgG包被红细胞或酵母聚糖颗粒的相互作用，但显著增强了它们通过补体受体进行吞噬的能力。讨论了这些发现在免疫介导炎症中的可能意义。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Intra-articular dissociation of the rheumatoid factor.类风湿因子的关节内解离
J Lab Clin Med. 1962 Sep;60:409-21.
3
4
Loss of Fc receptor activity after culture of human monocytes on surface-bound immune complexes. Mediation by cyclic nucleotides.人单核细胞在表面结合免疫复合物上培养后Fc受体活性丧失。环核苷酸的介导作用。
J Exp Med. 1980 Jan 1;151(1):32-44. doi: 10.1084/jem.151.1.32.
5
The interaction between human monocytes and red cells. Specificity for IgG subclasses and IgG fragments.人类单核细胞与红细胞之间的相互作用。对IgG亚类和IgG片段的特异性。
J Exp Med. 1970 Dec 1;132(6):1207-15. doi: 10.1084/jem.132.6.1207.
6
Effect of phagocytosis on membrane transport of nonelectrolytes.吞噬作用对非电解质膜转运的影响。
J Exp Med. 1971 Oct 1;134(4):1016-35. doi: 10.1084/jem.134.4.1016.
7
In vitro adherence of soluble immune complexes to macrophages.可溶性免疫复合物在体外对巨噬细胞的黏附作用。
J Exp Med. 1972 Sep 1;136(3):514-31. doi: 10.1084/jem.136.3.514.
8
Phagocytosis of immune complexes by macrophages. Different roles of the macrophage receptor sites for complement (C3) and for immunoglobulin (IgG).巨噬细胞对免疫复合物的吞噬作用。巨噬细胞补体（C3）受体位点和免疫球蛋白（IgG）受体位点的不同作用。
J Exp Med. 1972 Apr 1;135(4):780-92. doi: 10.1084/jem.135.4.780.
9
Receptors for human gamma G globulin on human neutrophils.人类中性粒细胞上的人γG球蛋白受体
J Clin Invest. 1970 Dec;49(12):2165-71. doi: 10.1172/JCI106435.
10
The phagosomes in rheumatoid synovial fluid leukocytes: a light, fluorescence, and electron microscope study.类风湿性滑液白细胞中的吞噬体：光镜、荧光显微镜及电镜研究
Arthritis Rheum. 1966 Feb;9(1):24-36. doi: 10.1002/art.1780090104.
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