Hopkins Walter J, Elkahwaji Johny E, Heisey Dennis M, Ott Christopher J
Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, USA.
J Infect Dis. 2003 Feb 1;187(3):418-23. doi: 10.1086/367963. Epub 2003 Jan 24.
In the present study, the inheritance of resistance and susceptibility to bladder and kidney infections in BALB/c, C3H/HeJ, F(1), and backcross mice was investigated, and the number of genes contributing to the phenotypes was estimated. Infections were induced in female mice by intravesical inoculation with Escherichia coli, and the number of bacteria in bladder and kidneys was quantified at 10 days. The (BALB/c x C3H/HeJ) F(1) mice had bladder and kidney infection intensities equivalent to those observed in the resistant BALB/c parents. Twelve percent of the (F(1) x C3H/HeJ) backcross mice had severe bladder infections, similar to the susceptible C3H/HeJ parents. Kidney infections ranging in intensity between those observed in BALB/c and C3H/HeJ parents were present in one-half of the backcross mice. Statistical analyses indicated that >/=1 gene is responsible for the increased susceptibility of C3H/HeJ mice and that the trait appears to be recessive.
在本研究中，对BALB/c、C3H/HeJ、F(1)代及回交小鼠膀胱和肾脏感染的抗性和易感性遗传进行了研究，并估计了对这些表型有影响的基因数量。通过向雌性小鼠膀胱内接种大肠杆菌诱导感染，并在第10天对膀胱和肾脏中的细菌数量进行定量。(BALB/c×C3H/HeJ)F(1)代小鼠膀胱和肾脏的感染强度与抗性BALB/c亲本中观察到的相当。12%的(F(1)×C3H/HeJ)回交小鼠有严重的膀胱感染，与易感的C3H/HeJ亲本相似。回交小鼠中有一半出现了强度介于BALB/c和C3H/HeJ亲本之间的肾脏感染。统计分析表明，≥1个基因导致C3H/HeJ小鼠易感性增加，且该性状似乎是隐性的。
