[Vacuolation effect of Helicobacter pylori on gastric epithelial cells].

This study was designed to observe vacuolation effect of Helicobacter pylori on gastric epithelial cells. The H. pylori isolates derived from patients with peptic ulcer, chronic gastritis and gastric cancer were plated on common selective medium and their vacuolation effects on SGC-7901 cells were compared. The percentage of H. pylori(Tox+) strain in clinical isolates from different gastroduodenal diseases had no significant difference. The toxicity of the H. pylori (Tox+) strain from peptic ulcer was significantly higher than that from chronic gasritis.