García-Rodríguez J A, García Sánchez J E, García García M I, Muñoz Bellido J L, Rodríguez Rincón M, Cordero Sánchez M
Departamento de Microbiología, Hospital Clínico Universitario, Salamanca.
Med Clin (Barc). 1990 Nov 17;95(17):648-52.
The presence of helicobacter pylori in the stomach in patients with clinical signs of gastroduodenal disease and its possible relationship with several clinical, endoscopic and anatomopathologic characteristics of the illness were prospectively evaluated in 359 patients. H. pylori was isolated from 388 samples in 216 patients (60% of colonization). In patients with endoscopic and, or, anatomopathologic evidence of gastroduodenal alterations the microorganism was isolated in 67% of the instances whereas it was observed in only 7% of the patients free of such alterations (p less than 0.001). The prevalence was 100% in cases of bulboduodenitis, 77% in patients with peptic ulcer, 66% in cases of gastritis, and 20% in neoplastic patients. The colonization index for duodenal ulcer was 80% and that of gastric ulcer 70%. Among the cases with gastritis the highest index corresponde to the superficial chronic gastritis (82%). We failed to observe clinical signs that allowed to envisage the presence or absence of H. pylori in the gastric mucosa.
对359例有胃十二指肠疾病临床症状的患者,前瞻性评估胃内幽门螺杆菌的存在情况及其与该疾病若干临床、内镜和解剖病理学特征的可能关系。从216例患者的388份样本中分离出幽门螺杆菌(定植率60%)。在内镜检查和/或解剖病理学检查有胃十二指肠病变证据的患者中,该微生物的分离率为67%,而在无此类病变的患者中仅为7%(p<0.001)。球部十二指肠炎症患者中的患病率为100%,消化性溃疡患者为77%,胃炎患者为66%,肿瘤患者为20%。十二指肠溃疡的定植指数为80%,胃溃疡为70%。在胃炎病例中,最高指数对应于浅表性慢性胃炎(82%)。我们未观察到能预示胃黏膜中幽门螺杆菌存在与否的临床症状。