Ji X, Shen M, Jia P, Long X
Department of Pathology, Chinese PLA General Hospital, Beijing, P.R. China.
J Environ Pathol Toxicol Oncol. 1993 Oct-Dec;12(4):209-12.
A retrospective study was performed on 500 consecutive gastric biopsies obtained from patients with a diagnosis of gastritis and gastric carcinoma. Overall, Helicobacter pylori was detected in 336 cases (67.2%); it was seen in 82.4% of patients with duodenal ulcer, 80.1% of patients with gastric ulcer, 76.1% of patients with chronic atrophic gastritis, 60.3% of patients with chronic superficial gastritis, and 32.1% of patients with gastric carcinoma. The gastric epithelium colonized by Helicobacter pylori showed characteristic changes including loss of the apical mucous portion of individual cells, dropout of epithelial cells, and erosions. There is a strong suggestion that the inflammation associated with Helicobacter pylori infection plays a role in the pathogenesis of gastric carcinoma.
对500例诊断为胃炎和胃癌的患者连续进行胃活检，进行回顾性研究。总体而言，336例（67.2%）检测到幽门螺杆菌；十二指肠溃疡患者中82.4%检测到幽门螺杆菌，胃溃疡患者中80.1%检测到，慢性萎缩性胃炎患者中76.1%检测到，慢性浅表性胃炎患者中60.3%检测到，胃癌患者中32.1%检测到。被幽门螺杆菌定植的胃上皮显示出特征性变化，包括单个细胞顶端黏液部分缺失、上皮细胞脱落和糜烂。强烈提示与幽门螺杆菌感染相关的炎症在胃癌发病机制中起作用。
