Belda José I, Artola Alberto, Alió Jorge
Department of Refractive Surgery, Instituto Oftalmológico de Alicante, Alicante, Spain.
J Refract Surg. 2003 Jan-Feb;19(1):70-1. doi: 10.3928/1081-597X-20030101-14.
Diffuse lamellar keratitis after laser in situ keratomileusis (LASIK) typically occurs between 1 and 7 days after the procedure, and its etiologic factor(s) remain unknown.
We describe a case of diffuse lamellar keratitis 6 months after uneventful LASIK in a 25-year-old woman.
Slit-lamp microscopy showed a diffuse infiltrate confined to the interface, extending to the visual axis, with no other relevant findings. Late on-set diffuse lamellar keratitis was our provisional diagnosis and treatment with topical corticosteroids was instituted, with rapid response and improvement of the clinical signs and symptoms.
This case supports the theory that a previously inert inciting agent could cause a delayed toxic or inflammatory response of the cornea several months after surgery.
准分子原位角膜磨镶术（LASIK）后弥漫性板层角膜炎通常发生在术后1至7天，其病因尚不清楚。
我们描述了一名25岁女性在顺利完成LASIK手术6个月后发生弥漫性板层角膜炎的病例。
裂隙灯显微镜检查显示弥漫性浸润局限于界面，延伸至视轴，无其他相关发现。迟发性弥漫性板层角膜炎是我们的初步诊断，并采用局部皮质类固醇进行治疗，临床体征和症状迅速缓解并改善。
该病例支持以下理论，即先前无活性的激发剂可能在手术后数月引起角膜延迟性毒性或炎症反应。
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