Chremos A N, Shen D, Gibaldi M, Proctor J D, Newman J H
J Pharm Sci. 1976 Jan;65(1):140-2. doi: 10.1002/jps.2600650136.
Blood levels and urinary excretion rates of bethanidine were determined in three normal human subjects following oral administration of a single dose of the drug. The postabsorptive decline of blood concentration with time was noticeably slower than the corresponding decline in the urinary excretion rate. The discrepancy can be attributed to a continual decrease in the renal clearance of bethanidine throughout the study. Therefore, pharmacokinetic modeling of urinary excretion data alone would lead to erroneous conclusions concerning the persistence of drug in the blood.
在三名正常人类受试者口服单剂量的苄乙胍后，测定了其血液中苄乙胍的水平和尿排泄率。吸收后血药浓度随时间的下降明显慢于尿排泄率的相应下降。这种差异可归因于在整个研究过程中苄乙胍的肾清除率持续下降。因此，仅对尿排泄数据进行药代动力学建模会得出有关药物在血液中持续存在的错误结论。
