Vyjayanthi S, Piskorowskyj N
Department of Obstetrics and Gynaecology, West Wales General Hospital, Carmarthen, UK.
J Obstet Gynaecol. 2002 Nov;22(6):669-71. doi: 10.1080/0144361021000020510.
Current RCOG guidelines advise that surgical termination should be offered to those within the 9-12 weeks gestation band. While auditing the quality of services offered for termination of pregnancy in our unit, it became apparent that many women presenting at this gestation were requesting a medical method. There has been little clinical research into medical method of abortion at this gestation. The aim of the study was to assess the efficacy of medical methods of termination at 9-12 weeks gestation. A retrospective analysis of 25 cases who underwent medical termination using a regime of mifepristone followed 48 hours later by a course of vaginal gemeprost was undertaken. Complete abortion was achieved in 96% of cases; 92% of women required no more than two pessaries to achieve complete abortion. All but one patient was suitable for discharge on the same day. One woman underwent surgical evacuation in view of heavy bleeding. We conclude that medical TOP is a safe alternative to surgical method at 9-12 weeks' gestation.
英国皇家妇产科医师学院(RCOG)目前的指南建议,对于妊娠9至12周的孕妇应提供手术终止妊娠的方式。在审核我们单位提供的终止妊娠服务质量时,很明显许多处于这个孕周的女性要求采用药物流产方法。目前针对这个孕周的药物流产方法几乎没有临床研究。本研究的目的是评估妊娠9至12周时药物流产方法的有效性。对25例采用米非司酮方案进行药物流产、48小时后再给予阴道用吉美前列素疗程的病例进行了回顾性分析。96%的病例实现了完全流产;92%的女性实现完全流产所需的阴道栓剂不超过两枚。除一名患者外,所有患者均适合在同一天出院。有一名女性因大出血接受了手术清宫。我们得出结论,在妊娠9至12周时,药物流产是手术流产的一种安全替代方法。