Niazi S, Chiou W L
J Pharm Sci. 1976 Jan;65(1):60-4. doi: 10.1002/jps.2600650111.
An intravenous dosage form of dichlorotetrafluoroethane, a common fluorocarbon aerosol propellant, was formulated in polyethylene glycol 400 for single dosing to unanesthetized dogs. A three-compartment open model was proposed for the disposition of this compound in dogs, with average half-lives of 1.3, 9.6, and 50.8 min for the three disposition phases. An analysis of tissue compartment distribution following a single dose showed that it took about 2 hr to achieve pseudo-distribution equilibration, following which more than 90% of the propellant remaining in the body was retained in the tissue compartments. Pulmonary clearance and volumes of distribution were calculated considering the first-pass effect through the lungs. The volume of distribution was approximately 10 times the body weight in terms of blood concentration, and about 84% of the propellant was cleared from the blood passing through the lungs in each cycle.
一种常见的氟碳气雾剂推进剂二氯四氟乙烷的静脉剂型，以聚乙二醇400配制，用于对未麻醉的犬单次给药。提出了一个三室开放模型来描述该化合物在犬体内的处置过程，三个处置阶段的平均半衰期分别为1.3、9.6和50.8分钟。单次给药后组织隔室分布分析表明，大约需要2小时才能达到伪分布平衡，此后体内剩余的推进剂中超过90%保留在组织隔室中。考虑到通过肺部的首过效应，计算了肺部清除率和分布容积。就血药浓度而言，分布容积约为体重的10倍，每个循环中约84%的推进剂从流经肺部的血液中清除。
