Niazi S, Chiou W L
J Pharm Sci. 1975 Sep;64(9):1538-41. doi: 10.1002/jps.2600640926.
Solubilities of the three most commonly used fluorocarbon aerosol propellants were determined in the blood and plasma of humans, monkeys, dogs, rats, and mice. Differences as large as approximately fourfold in blood and more than 33-fold in plasma were found in different species. The partitioning of fluorocarbons between blood cells and plasma showed even greater differences between species. An indirect method was suggested for the calculation of plasma concentrations from total blood concentrations. A comparative evaluation was reported for the nonprotein bound fractions of fluorocarbons in the blood samples of various species. A correlation was drawn for the pharmacokinetic properties of the fluorocarbons within and between species, and a rationale was provided for the extrapolation of toxicity data from animals to humans.
测定了三种最常用的碳氟化合物气溶胶推进剂在人、猴、狗、大鼠和小鼠的血液和血浆中的溶解度。发现不同物种之间血液中的溶解度差异高达约四倍，血浆中的溶解度差异超过33倍。碳氟化合物在血细胞和血浆之间的分配在不同物种之间显示出更大的差异。提出了一种从全血浓度计算血浆浓度的间接方法。报告了对不同物种血液样本中碳氟化合物非蛋白结合部分的比较评估。得出了碳氟化合物在物种内部和物种之间的药代动力学性质的相关性，并为从动物到人的毒性数据外推提供了理论依据。
