Koller G, Bondy B, Preuss U W, Bottlender M, Soyka M
Psychiatrische Klinik und Poliklinik der LMU München, Nussbaumstrasse 7, 80336 München, Germany.
Alcohol Alcohol. 2003 Jan-Feb;38(1):31-4. doi: 10.1093/alcalc/agg003.
We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits.
The repeat number (3-5) of the MAOA polymorphism was determined in 169 male alcoholic subjects and 72 controls of German descent. Behavioural and personality traits were evaluated using the Brown-Goodwin Assessment for History of Lifetime Aggression, the Buss Durkee Hostility Inventory, as well as the Barrat Impulsiveness Score. A median split in Brown-Goodwin, Buss Durkee Irritability, Buss Durkee Assault and Barrat Impulsiveness Score was conducted.
High scores were found, i.e. 47.9% in Brown-Goodwin, 65.7% in Buss Durkee Irritability, 63.3% in Buss Durkee Assault and 59.8% in Barrat Impulsiveness Scale, indicating high impulsiveness, irritability and antisocial behaviour. Based on the results of these questionnaires, we detected no significant differences between the frequency of the three-repeat allele and high or low scores in alcoholics and controls.
Taken together, these findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits.
我们分析了X染色体单胺氧化酶A（MAOA）基因启动子区域的MAOAuVNTR功能多态性。据报道，具有三重复等位基因的基因型与反社会及冲动特质有关。
在169名德国裔男性酒精依赖者和72名对照者中确定MAOA多态性的重复次数（3 - 5次）。使用布朗 - 古德温终身攻击史评估、巴斯 - 杜克敌意量表以及巴拉特冲动性评分来评估行为和人格特质。对布朗 - 古德温、巴斯 - 杜克易怒性、巴斯 - 杜克攻击性和巴拉特冲动性评分进行中位数划分。
发现高分情况，即在布朗 - 古德温评估中占47.9%，在巴斯 - 杜克易怒性量表中占65.7%，在巴斯 - 杜克攻击性量表中占63.3%，在巴拉特冲动性量表中占59.8%，表明存在高冲动性、易怒性和反社会行为。基于这些问卷结果，我们未发现酒精依赖者和对照者中三重复等位基因频率与高分或低分之间存在显著差异。
综上所述，这些发现表明MAOAuVNTR 30碱基对多态性的三重复等位基因与冲动和攻击性人格特质无关。
