Beckett P A, Howarth P H
Respiratory Cell Molecular Biology Division, Southampton General Hospital, Southampton SO16 6YD, UK.
Thorax. 2003 Feb;58(2):163-74. doi: 10.1136/thorax.58.2.163.
Over the last few decades attention has largely focused on airway inflammation in asthma, but more recently it has been appreciated that there are important structural airway changes which have been grouped together under the term "airway remodelling". It is only now that questions have been asked about the impact of treatment on these structural changes. This review examines the nature of these structural airway changes, the mechanisms of their generation, their potential consequences, and what is known about the ability of anti-asthma treatments to modulate these changes.
在过去几十年里,注意力主要集中在哮喘中的气道炎症上,但最近人们认识到存在重要的气道结构改变,这些改变被统称为“气道重塑”。直到现在,才有人开始探讨治疗对这些结构改变的影响。这篇综述考察了这些气道结构改变的本质、其产生机制、潜在后果,以及关于抗哮喘治疗调节这些改变的能力的已知情况。