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通过小鼠对再次感染的抗性比较两种杜氏利什曼原虫地理株。

Comparison of two geographic strains of Leishmania donovani by resistance of mice to superinfection.

作者信息

Holbrook T W, Palczuk N C

出版信息

Am J Trop Med Hyg. 1975 Jul;24(4):704-6. doi: 10.4269/ajtmh.1975.24.704.

DOI:10.4269/ajtmh.1975.24.704
PMID:125553
Abstract

Groups of mice were injected with Leishmania donovani strains Et (Burma) or IS (Sudan) and the courses of infection were followed. Between days 20 and 30 after infection by treatment with pentostam. Et- and 1S-recovered mice were challenged by intravenous injection of amastigotes of each strain. Although resistance to superinfection was apparent the L. donovani strains could not be differentiated by this method.

摘要

将小鼠分组,注射杜氏利什曼原虫菌株Et(缅甸株)或IS(苏丹株),并跟踪感染过程。感染后第20至30天,用喷他脒进行治疗。对Et株和IS株感染后恢复的小鼠通过静脉注射各菌株的无鞭毛体进行攻击。尽管对再次感染的抵抗力很明显,但用这种方法无法区分杜氏利什曼原虫菌株。

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