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产科诊所的围产期药物滥用干预可降低不良新生儿结局。

Perinatal substance abuse intervention in obstetric clinics decreases adverse neonatal outcomes.

作者信息

Armstrong Mary Anne, Gonzales Osejo Veronica, Lieberman Leslie, Carpenter Diane M, Pantoja Philip M, Escobar Gabriel J

机构信息

Kaiser Permanente Medical Care Program, Division of Research, Perinatal Research Unit, Oakland, CA 94611, USA.

出版信息

J Perinatol. 2003 Jan;23(1):3-9. doi: 10.1038/sj.jp.7210847.

Abstract

OBJECTIVE

To evaluate the effect of Early Start, a managed care organization's obstetric clinic-based perinatal substance abuse treatment program, on neonatal outcomes.

STUDY DESIGN

Study subjects were 6774 female Kaiser Permanente members who delivered babies between July 1, 1995 and June 30, 1998 and were screened by completing prenatal substance abuse screening questionnaires and urine toxicology screening tests. Four groups were compared: substance abusers screened, assessed, and treated by Early Start ("SAT," n=782); substance abusers screened and assessed by Early Start who had no follow-up treatment ("SA," n=348); substance abusers who were only screened ("S," n=262); and controls who screened negative ("C," n=5382).

RESULTS

Infants of SAT women had assisted ventilation rates (1.5%) similar to control infants (1.4%), but lower than the SA (4.0%, p=0.01) and S groups (3.1%, p=0.12). Similar patterns were found for low birth weight and preterm delivery.

CONCLUSION

Improved neonatal outcomes were found among babies whose mothers received substance abuse treatment integrated with prenatal care. The babies of SAT women did as well as control infants on rates of assisted ventilation, low birth weight, and preterm delivery. They had lower rates of these three neonatal outcomes than infants of either SA or S women.

摘要

目的

评估“早期干预”(一项管理式医疗组织基于产科诊所的围产期药物滥用治疗项目)对新生儿结局的影响。

研究设计

研究对象为6774名凯撒医疗集团的女性成员,她们在1995年7月1日至1998年6月30日期间分娩,并通过填写产前药物滥用筛查问卷和尿液毒理学筛查测试进行筛查。比较了四组:经“早期干预”筛查、评估和治疗的药物滥用者(“SAT”,n = 782);经“早期干预”筛查和评估但未接受后续治疗的药物滥用者(“SA”,n = 348);仅接受筛查的药物滥用者(“S”,n = 262);以及筛查结果为阴性的对照组(“C”,n = 5382)。

结果

SAT组女性的婴儿辅助通气率(1.5%)与对照组婴儿(1.4%)相似,但低于SA组(4.0%,p = 0.01)和S组(3.1%,p = 0.12)。低出生体重和早产也发现了类似的模式。

结论

母亲接受与产前护理相结合的药物滥用治疗的婴儿,其新生儿结局得到改善。SAT组女性的婴儿在辅助通气率、低出生体重和早产率方面与对照组婴儿相当。这三组新生儿结局的发生率低于SA组或S组女性的婴儿。

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