Kawasaki Teruaki, Oka Nobuyuki, Tachibana Hisao, Akiguchi Ichiro, Shibasaki Hiroshi
Department of Neurology, Kyoto University Graduate School of Medicine, Sakyo-ku, Japan.
Acta Neuropathol. 2003 Mar;105(3):203-8. doi: 10.1007/s00401-002-0630-9. Epub 2002 Dec 3.
Three transcription factors, Krox20 (EGR2), Oct6 (SCIP/Tst1) and Sox10, are considered necessary for transition from the nonmyelinating to the myelinating stage of Schwann cell development. We immunohistochemically studied Oct6 expression in peripheral nerve specimens from 25 patients with various diseases including Charcot-Marie-Tooth disease type 1A (CMT1A). Oct6 was present in cytoplasm of Schwann cells associated with normal-appearing myelinated nerve fibers, but not in nuclei. Expression was seen in nuclei of Schwann cells in the early phase of acute axonal degeneration; nuclear expression peaked at the regenerative stage. Schwann cells forming "onion bulbs" expressed Oct6 in chronic inflammatory demyelinating polyneuropathy (CIDP), but showed minimal expression in CMT1A, reflecting their proliferative activity in CIDP. Nerves showing chronic axonal loss had no expression. Oct6, then, may be a marker for dedifferentiation of adult Schwann cells and active nerve regeneration.
三种转录因子，即Krox20（EGR2）、Oct6（SCIP/Tst1）和Sox10，被认为是雪旺细胞发育从无髓鞘阶段过渡到有髓鞘阶段所必需的。我们采用免疫组织化学方法研究了25例包括1A型腓骨肌萎缩症（CMT1A）在内的各种疾病患者外周神经标本中Oct6的表达情况。Oct6存在于与外观正常的有髓神经纤维相关的雪旺细胞的细胞质中，但不存在于细胞核中。在急性轴索性变性早期，雪旺细胞核中有Oct6表达；在再生阶段，核表达达到峰值。在慢性炎性脱髓鞘性多发性神经病（CIDP）中，形成“洋葱球”的雪旺细胞表达Oct6，但在CMT1A中表达极少，这反映了它们在CIDP中的增殖活性。显示慢性轴索丢失的神经无Oct6表达。因此，Oct6可能是成年雪旺细胞去分化和活跃神经再生的标志物。
