生物活性玻璃陶瓷在胫骨平台骨折治疗中的应用
[Use of bioactive glass ceramics in the treatment of tibial plateau fractures].
作者信息
Urban K
机构信息
Ortopedická klinika FN a LF UK, Hradec Králové.
出版信息
Acta Chir Orthop Traumatol Cech. 2002;69(5):295-301.
PURPOSE OF THE STUDY
The surgical treatment of proximal tibia fractures requires a reduction and fixation of the split condyle, elevation of the depressed interfragment of articular surface. The golden standard is the application of autogenous bone grafts for filling in the defect in the cancellous bone of the tibial condyle. Bioactive glass-ceramics material may be successfully used for the filling. Gass-ceramics BAS-O is biocompatible and bioactive and has also suitable mechanical properties and therefore it was used in combination with autogenous bone marrow in order to speed up osteogenesis.
MATERIAL
The study covered 12 patients, 4 men and 8 women, with a fracture of the proximal tibia classified according to AO as type B3.1, B3.2 and C3.2. The average follow-up period was 5.5 years (range, 2 to 8 years).
METHOD
After the assessment of the type of fracture and revision of soft tissues the depressed interfragment of articular surface was elevated and the defect was completely filled with BAS-O granules in combination with 10 ml of autogenous bone marrow. The broken condyle was fixed by screws or buttress plate. During the first year the process of healing was checked by radiographs at 3-month intervals. All 12 patients were invited for a follow-up examination where the radiograph of the proximal tibia was assessed in two projections and the clinical condition was evaluated using Rasmussen criteria.
RESULTS
According to the Rasmussen criteria 12 patients achieved the value of 21-29 points with the average of 26.4 of 30 possible points. The volume of the BAS-O filling was 7.1-44.3 ccm and did not change throughout the whole period of the follow-up. The depression of an interfragment of articular surface prior to operation was 3-17 mm, average 6.3 mm. The residual depression after the operation was 0-4 mm, average 1.7 mm. No symptoms of loosening, extrusion or surrounding of the BAS-O material by fibrous tissue was found. The integration with the surrounding bone occurred during the first 3 months.
DISCUSSION
The bioactive coral hydroxyapatite has been successfully used to fill similar defects by a number of authors. Among the benefits of BAS-O granular system is an easy handling and a fast integration with the bone tissue of the recipient due to the development of a hydroxyapatite layer on its surface after the contact with tissue fluid. Autologous bone marrow was added to the system in order to initiate osteogenesis and a faster healing of the defect. The mentioned material is suitable also from the mechanical viewpoint as neither deformation nor resorption was found in the followed-up patients. We reduced the surgery duration and morbidity and improved the patients comfort.
CONCLUSIONS
Part of the surgical management of the fracture of the tibial plateau with a depressed segment of subchondral bone is its elevation. For filling in of the traumatic defect in the cancellous bone of the proximal tibia the bioactive, glass-ceramics, granular material BAS-O may be successfully used. Mechanical and chemical properties (compression strength, non-resorption) ensure its stable position in the filling as well as a constant volume. Osteointegration was accelerated by adding 10 ml of autologous bone marrow. The use of the glass-ceramics material reduces the surgery duration, improves the patient's comfort and decreases the probability of incidence of complications.
研究目的
胫骨近端骨折的手术治疗需要对劈裂的髁部进行复位和固定,抬高关节面塌陷的骨折块。金标准是应用自体骨移植来填充胫骨髁部松质骨的缺损。生物活性玻璃陶瓷材料可成功用于填充。玻璃陶瓷BAS - O具有生物相容性和生物活性,也具有合适的力学性能,因此将其与自体骨髓联合使用以加速骨生成。
材料
该研究涵盖12例患者,4例男性和8例女性,胫骨近端骨折根据AO分类为B3.1、B3.2和C3.2型。平均随访期为5.5年(范围2至8年)。
方法
在评估骨折类型并修复软组织后,抬高关节面塌陷的骨折块,并用BAS - O颗粒联合10毫升自体骨髓完全填充缺损。用螺钉或支撑钢板固定骨折的髁部。在第一年,每隔3个月通过X线片检查愈合过程。邀请所有12例患者进行随访检查,在两个投照方向评估胫骨近端的X线片,并使用拉斯穆森标准评估临床状况。
结果
根据拉斯穆森标准,12例患者获得21 - 29分,在30分的总分中平均为26.4分。BAS - O填充物的体积为7.1 - 44.3立方厘米,在整个随访期间没有变化。术前关节面骨折块的塌陷为3 - 17毫米,平均6.3毫米。术后残余塌陷为0 - 4毫米,平均1.7毫米。未发现BAS - O材料有松动、挤出或被纤维组织包绕的症状。在最初3个月内与周围骨发生融合。
讨论
许多作者已成功使用生物活性珊瑚羟基磷灰石来填充类似的缺损。BAS - O颗粒系统的优点包括易于操作,并且由于与组织液接触后在其表面形成羟基磷灰石层,能快速与受体骨组织融合。向该系统中添加自体骨髓以启动骨生成并更快地愈合缺损。从力学角度来看,上述材料也是合适的,因为在随访患者中未发现变形或吸收。我们缩短了手术时间和发病率,提高了患者的舒适度。
结论
胫骨平台骨折伴软骨下骨塌陷节段的手术治疗部分是对其进行抬高。对于填充胫骨近端松质骨的创伤性缺损,生物活性玻璃陶瓷颗粒材料BAS - O可成功使用。其力学和化学性质(抗压强度、无吸收)确保其在填充中的稳定位置以及恒定体积。添加10毫升自体骨髓加速了骨整合。使用玻璃陶瓷材料缩短了手术时间,提高了患者的舒适度,并降低了并发症发生的概率。