Leonard D P, Kidson M A, Brown J G, Shannon P J, Taryan S
Aust N Z J Psychiatry. 1975 Jun;9(2):115-8. doi: 10.3109/00048677509159834.
Six patients with a family history of Huntington's chorea (HC) participated in a double blind crossover trial involving four treatments--lithium carbonate, haloperidol, lithium carbonate and haloperidol, and placebo. Each treatment was administered for three weeks and, at the end of each treatment period, assessments were made of chorea and a number of psychological variables. None of the treatments significantly affected chorea measurements. With regard to the psychological variables, the levels of irritability, the frequency of angry outbursts and depression did appear to be affected in some patients by the treatment. Three patients improved on a combination of lithium carbonate and haloperidol while the remaining three did not. Haloperidol alone significantly raised depression ratings above levels for other treatments including placebo. It is suggested that lithium carbonate and haloperidol together should be seriously considered in the treatment of HC when patients are excessively irritable and impulsive.
六名有亨廷顿舞蹈病（HC）家族病史的患者参与了一项双盲交叉试验，该试验涉及四种治疗方法——碳酸锂、氟哌啶醇、碳酸锂与氟哌啶醇联用以及安慰剂。每种治疗方法持续给药三周，并且在每个治疗阶段结束时，对舞蹈病症状以及一些心理变量进行评估。没有一种治疗方法对舞蹈病测量结果产生显著影响。关于心理变量，易怒程度、愤怒爆发频率和抑郁水平在一些患者中似乎确实受到了治疗的影响。三名患者在碳酸锂和氟哌啶醇联用时病情有所改善，而其余三名患者则没有。单独使用氟哌啶醇会使抑郁评分显著高于包括安慰剂在内的其他治疗方法。建议当患者过度易怒和冲动时，在HC的治疗中应认真考虑联合使用碳酸锂和氟哌啶醇。
