Amity Institute of Pharmacy, Lucknow, Amity University Uttar Pradesh, Noida, UP, India.
Amity Institute of Pharmacy, Amity University Maharashtra, Mumbai, Maharashtra, India.
Curr Mol Med. 2024;24(8):1004-1032. doi: 10.2174/1566524023666230907093451.
Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and Friedrich ataxia are all incurable neurodegenerative diseases defined by the continuous progressive loss of distinct neuronal subtypes. Despite their rising prevalence among the world's ageing population, fewer advances have been made in the concurrent massive efforts to develop newer drugs. Recently, there has been a shift in research focus towards the discovery of new therapeutic agents for neurodegenerative diseases. In this review, we have summarized the recently developed therapies and their status in the management of neurodegenerative diseases.
阿尔茨海默病、帕金森病、肌萎缩性侧索硬化症、亨廷顿病和弗里德里希共济失调都是由特定神经元亚型的持续进行性丧失定义的不可治愈的神经退行性疾病。尽管它们在世界老年人口中的患病率不断上升,但在同时进行的大量开发新药的努力中,取得的进展较少。最近,研究重点已经转向发现治疗神经退行性疾病的新治疗剂。在这篇综述中,我们总结了最近开发的疗法及其在神经退行性疾病治疗中的现状。