Kawahito Shinji, Maeda Tomohiro, Motomura Tadashi, Takano Tamaki, Nonaka Kenji, Linneweber Joerg, Ichikawa Seiji, Kawamura Masaki, Glueck Julie, Fujisawa Akira, Makinouchi Kenzo, Nosé Yukihiko
Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
ASAIO J. 2003 Jan-Feb;49(1):112-6. doi: 10.1097/00002480-200301000-00018.
Centrifugal blood pumps are used widely for cardiopulmonary bypass, as ventricular assist devices, and for extracorporeal membrane oxygenation (ECMO). However, there is no centrifugal blood pump that is suitable for long-term ECMO. The authors developed the Gyro C1E3 centrifugal blood pump (Kyocera Corporation, Kyoto, Japan), which has superior antithrombogenic, antitraumatic, and hydraulic features in comparison with the conventional centrifugal blood pumps. Five ex vivo long-term durability tests of the Gyro C1E3 were performed using healthy miniature calves. The ECMO circuit was composed of a prototype hollow fiber silicone membrane oxygenator and a Gyro C1E3 pump. Venous blood was drained from the left jugular vein of a calf, passed through the oxygenator and infused into the left carotid artery using a Gyro C1E3. Ex vivo studies were performed from 7 to 15 days at a blood flow rate of 1 L/min. During this period, the Gyro C1E3 demonstrated a stable performance without exchanging the pump. Bleeding complications were the major reason for termination of each experiment. Rotational speed was maintained around 2,000 rpm. All five calves demonstrated neither abnormal signs nor abnormal blood examination data throughout the experiment. Neither clot nor thrombus formations were found during the necropsy in the cannula or pump nor were infarctions observed in any of the major organs. In conclusion, the Gyro C1E3 showed a stable and reliable performance during long-term ex vivo bovine experiments under the conditions tested.
离心式血泵广泛应用于体外循环、作为心室辅助装置以及体外膜肺氧合（ECMO）。然而，目前尚无适用于长期ECMO的离心式血泵。作者研发了Gyro C1E3离心式血泵（日本京瓷公司，京都），与传统离心式血泵相比，它具有卓越的抗血栓形成、抗创伤和水力特性。使用健康的小型犊牛对Gyro C1E3进行了五次体外长期耐久性测试。ECMO回路由一个原型中空纤维硅膜氧合器和一个Gyro C1E3泵组成。静脉血从小牛的左颈静脉引出，通过氧合器，再使用Gyro C1E3泵注入左颈动脉。在血流速度为1 L/min的情况下进行了7至15天的体外研究。在此期间，Gyro C1E3表现出稳定的性能，无需更换泵。出血并发症是每个实验终止的主要原因。转速维持在2000 rpm左右。在整个实验过程中，所有五只小牛均未表现出异常体征或异常血液检查数据。尸检时，在插管或泵中均未发现血栓形成，任何主要器官也均未观察到梗死。总之，在测试条件下，Gyro C1E3在长期体外牛实验中表现出稳定可靠的性能。
