Pasić Aida, Ceović Romana, Lipozencić Jasna, Husar Karmela, Susić Slobodna Murat, Skerlev Mihael, Hrsan Damir
Department of Dermatology and Venerology, Zagreb University Hospital Center, Zagreb, Croatia.
Pediatr Dermatol. 2003 Jan-Feb;20(1):71-7. doi: 10.1046/j.1525-1470.2003.03016.x.
The treatment of children with psoriasis, atopic dermatitis (AD), pityriasis lichenoides, and scleroderma poses a therapeutic problem because all therapeutic options are associated with numerous side effects. Therefore ultraviolet A and B (UVA and UVB) phototherapy is presented as a possible alternative to some of these therapies, primarily topical and systemic corticosteroids, in children. Our results in treating children with phototherapy and psoralen plus UVA (PUVA) bath phototherapy over the past 5 years are reported. UVB therapy (TL01) was used in 20 psoriatic children (6 boys, 14 girls; ages 6-14 years) during the stage of disease exacerbation and in 9 children (3 boys, 6 girls; ages 8-16 years) with pityriasis lichenoides. Combined UVA/UVB phototherapy was applied in 21 AD children (7 boys, 14 girls; ages 4-15 years). Photochemotherapy with local application of a PUVA bath was used in six children (2 boys, 4 girls; ages 9-16 years) with circumscribed scleroderma and in one girl with systemic scleroderma. All children received short courses of phototherapy with either no maintenance or short maintenance. All three therapeutic protocols resulted in a certain degree of improvement in most of the study patients. None of the patients exhibited any early phototherapy side effects. We conclude that phototherapy and PUVA bath are valuable and safe therapeutic options for selected children who do not respond to other treatments.
治疗患有银屑病、特应性皮炎(AD)、苔藓样糠疹和硬皮病的儿童存在治疗难题,因为所有治疗选择都伴有众多副作用。因此,紫外线A和B(UVA和UVB)光疗被视为这些疗法(主要是局部和全身用皮质类固醇)的一种可能替代方案用于儿童。本文报告了我们在过去5年中用光疗和补骨脂素加UVA(PUVA)浴光疗治疗儿童的结果。UVB疗法(TL01)用于20名处于疾病加重期的银屑病儿童(6名男孩,14名女孩;年龄6 - 14岁)以及9名患有苔藓样糠疹的儿童(3名男孩,6名女孩;年龄8 - 16岁)。联合UVA/UVB光疗应用于21名AD儿童(7名男孩,14名女孩;年龄4 - 15岁)。局部应用PUVA浴的光化学疗法用于6名患有局限性硬皮病的儿童(2名男孩,4名女孩;年龄9 - 16岁)和一名患有系统性硬皮病的女孩。所有儿童均接受短疗程光疗,要么不进行维持治疗,要么进行短期维持治疗。所有三种治疗方案在大多数研究患者中都带来了一定程度的改善。没有患者出现任何早期光疗副作用。我们得出结论,对于对其他治疗无反应的特定儿童,光疗和PUVA浴是有价值且安全的治疗选择。