尿路上皮癌中uCyt+在检测和监测中的作用。

Role of uCyt+ in the detection and surveillance of urothelial carcinoma.

作者信息

Lodde Michele, Mian Christine, Negri Giovanni, Berner Lukas, Maffei Nicola, Lusuardi Lukas, Palermo Salvatore, Marberger Michael, Brssner Clemens, Pycha Armin

机构信息

Department of Urology and Pathology, General Hospital of Bolzano, Bolzano, Italy.

出版信息

Urology. 2003 Jan;61(1):243-7. doi: 10.1016/s0090-4295(02)02073-3.

DOI:10.1016/s0090-4295(02)02073-3

PMID:12559316

Abstract

OBJECTIVES

To test the clinical value and role of uCyt+ as a noninvasive tool for the detection and surveillance of urothelial carcinoma.

METHODS

Included in this prospective study were 235 patients (mean age 71.5 years, range 32 to 86). Of these, 98 patients had signs and symptoms suggestive of bladder cancer and 137 patients were being followed up after complete transurethral resection of superficial urothelial cancer (UC). All patients underwent urinary cytology and the uCyt+ test performed on ThinPrep (thin layer). All underwent subsequent cystoscopy and evaluation of any suspicious lesion by biopsy.

RESULTS

A total of 102 patients had histologically proven UC. In the group of patients with signs and symptoms suspicious of UC, the sensitivity of cytology increased from 5% for G1 to 84.6% for G3 tumors; for uCyt+, it was 85% for G1, 100% for G2, and 92.3% for G3 tumors. Combining cytology and uCyt+, the sensitivity was 85% for G1 and 100% for G2 and G3. In the group of follow-up patients, the sensitivity of cytology increased from 4.3% for G1 to 94.4% for G3 tumors; for uCyt+, it was 78.2% for G1, 70% for G2, and 94.4% for G3 tumors. Combining both tests, the sensitivity was 78.2% for G1, 90% for G2, and 100% for G3.

CONCLUSIONS

The uCyt+ is a valid test in the detection of UC of all grades and stages. It improves the sensitivity of cytology in low-grade tumors. The two tests combined may be a highly sensitive method to detect UC early in detection and surveillance.

摘要

目的

检测uCyt+作为一种用于尿路上皮癌检测和监测的非侵入性工具的临床价值及作用。

方法

本前瞻性研究纳入了235例患者（平均年龄71.5岁，范围32至86岁）。其中，98例患者有提示膀胱癌的体征和症状，137例患者在浅表性尿路上皮癌（UC）经尿道完全切除术后接受随访。所有患者均接受了尿液细胞学检查以及在ThinPrep（薄层）上进行的uCyt+检测。所有患者随后均接受了膀胱镜检查，并通过活检对任何可疑病变进行评估。

结果

共有102例患者经组织学证实患有UC。在有可疑UC体征和症状的患者组中，细胞学检查的敏感性从G1期肿瘤的5%提高到G3期肿瘤的84.6%；对于uCyt+检测，G1期肿瘤为85%，G2期肿瘤为100%，G3期肿瘤为92.3%。将细胞学检查和uCyt+检测相结合，G1期肿瘤的敏感性为85%，G2期和G3期肿瘤为100%。在随访患者组中，细胞学检查的敏感性从G1期肿瘤的4.3%提高到G3期肿瘤的94.4%；对于uCyt+检测，G1期肿瘤为78.2%，G2期肿瘤为70%，G3期肿瘤为94.4%。将两种检测相结合，G1期肿瘤的敏感性为78.2%，G2期肿瘤为90%，G3期肿瘤为100%。