铝冶炼工人的膀胱癌筛查

Bladder cancer screening in aluminum smelter workers.

作者信息

Taiwo Oyebode A, Slade Martin D, Cantley Linda F, Tessier-Sherman Baylah, Galusha Deron, Kirsche Sharon R, Donoghue A Michael, Cullen Mark R

机构信息

From the Yale Occupational and Environmental Medicine Program (Dr Taiwo, Ms Slade, Ms Cantley, Ms Tessier-Sherman, Mr Galusha, and Ms Kirsche), Yale University School of Medicine, New Haven, Conn; Alcoa, Inc (Dr Donoghue), Western Australia; and General Medical Disciplines (Dr Cullen), Stanford University School of Medicine, Calif.

出版信息

J Occup Environ Med. 2015 Apr;57(4):421-7. doi: 10.1097/JOM.0000000000000377.

DOI:10.1097/JOM.0000000000000377

PMID:25525927

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4374722/

Abstract

OBJECTIVE

To present results of a bladder cancer screening program conducted in 18 aluminum smelters in the United States from January 2000 to December 2010.

METHODS

Data were collected on a cohort of workers with a history of working in coal tar pitch volatile exposed areas including urine analysis for conventional cytology and ImmunoCyt/uCyt+ assay.

RESULTS

ImmunoCyt/uCyt+ and cytology in combination showed a sensitivity of 62.30%, a specificity of 92.60%, a negative predictive value of 99.90%, and a positive predictive value of 2.96%. Fourteen cases of bladder cancer were detected, and the standardized incidence ratio of bladder cancer was 1.18 (95% confidence interval, 0.65 to 1.99). Individuals who tested positive on either test who were later determined to be cancer free had undergone expensive and invasive tests.

CONCLUSIONS

Evidence to support continued surveillance of this cohort has not been demonstrated.

摘要

目的

呈现2000年1月至2010年12月在美国18家铝冶炼厂开展的膀胱癌筛查项目的结果。

方法

收集了一组有在煤焦油沥青挥发物暴露区域工作史的工人的数据，包括用于传统细胞学检查的尿液分析以及免疫细胞/uCyt+检测。

结果

免疫细胞/uCyt+与细胞学检查相结合显示，灵敏度为62.30%，特异度为92.60%，阴性预测值为99.90%，阳性预测值为2.96%。检测出14例膀胱癌病例，膀胱癌的标准化发病比为1.18（95%置信区间，0.65至1.99）。两种检测中任一种检测呈阳性但后来被确定无癌症的个体都接受了昂贵且有创的检查。