Eisenstein R, Larsson S E, Kuettner K E, Sorgente N, Hascal V C
Atherosclerosis. 1975 Jul-Aug;22(1):1-17. doi: 10.1016/0021-9150(75)90064-7.
Water and glycosaminoglycan contents were measured in upper and lower thoracic aortas of claves and steers. The ability of various molarities of guanidine hydrochloride to extract glycosaminoglycans from these tissues was assessed. Some glycosaminoglycans seem to be more resistant to extraction than others. A procedure is described for the isolation of a proteoglycan. The molecule appears to contain both dermatan sulfate and chondroitin sulfate. It also seems to be less dense than cartilage proteoglycans extracted by similar methods as assessed by its behavior in centrifugal fields. The properties, locus and biological activities of this molecule are currently being studied.
对犊牛和公牛的胸主动脉上段和下段的水分及糖胺聚糖含量进行了测量。评估了不同摩尔浓度的盐酸胍从这些组织中提取糖胺聚糖的能力。一些糖胺聚糖似乎比其他糖胺聚糖更难提取。本文描述了一种分离蛋白聚糖的方法。该分子似乎同时含有硫酸皮肤素和硫酸软骨素。通过其在离心场中的行为评估，它的密度似乎也比用类似方法提取的软骨蛋白聚糖低。目前正在研究该分子的特性、位置和生物活性。
