Klistorner Alexandr, Graham Stuart L
Department of Ophthalmology, The University of Sydney, Darlington, NSW, Australia.
Department of Ophthalmology, Macquarie University, Sydney, NSW, Australia.
Front Neurosci. 2021 Oct 29;15:725187. doi: 10.3389/fnins.2021.725187. eCollection 2021.
Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), characterized by inflammation, demyelination, neuro-axonal loss, and gliosis. Inflammatory demyelinating lesions are a hallmark of the disease. Spontaneous remyelination, however, is often incomplete and strategies that promote remyelination are needed. As a result, accurate and sensitive measures of remyelination are necessary. The visual pathway provides a unique opportunity for assessment of myelin damage and repair in the MS-affected brain since it is highly susceptible to damage in MS and is a very frequent site of MS lesions. The visually evoked potential (VEP), an event-related potential generated by the striate cortex in response to visual stimulation, is uniquely placed to serve as a biomarker of the myelination along the visual pathway. The multifocal VEP (mfVEP) represents a most recent addition to the array of VEP stimulations. This article provides a current view on the role of mfVEP as a biomarker of demyelination, spontaneous remyelination, and myelin repair in MS.
多发性硬化症（MS）是一种中枢神经系统（CNS）的复杂疾病，其特征为炎症、脱髓鞘、神经轴突损失和胶质增生。炎性脱髓鞘病变是该疾病的一个标志。然而，自发的髓鞘再生往往不完全，因此需要促进髓鞘再生的策略。结果，准确且敏感的髓鞘再生测量方法是必要的。视觉通路为评估MS影响的大脑中的髓鞘损伤和修复提供了独特的机会，因为它在MS中极易受损，且是MS病变的常见部位。视觉诱发电位（VEP）是由纹状皮质对视觉刺激产生的一种事件相关电位，非常适合作为视觉通路髓鞘化的生物标志物。多焦点VEP（mfVEP）是VEP刺激阵列中的最新成员。本文提供了关于mfVEP作为MS中脱髓鞘、自发髓鞘再生和髓鞘修复生物标志物作用的当前观点。
