Fehm H L, Voigt K H, Lang R, Beinert K E, Raptis S, Pfeiffer E F
Klin Wochenschr. 1976 Feb 15;54(4):173-5. doi: 10.1007/BF01468882.
Somatostatin (250 mug as a bolus i.v. and 250 mug as a 1-hr infusion) was administered to 5 patients with adrenal insufficiency of different origin. In each patient a sustained, progressive fall in plasma ACTH was observed during the infusion period. The mean maximal reduction in plasma ACTH was 43.8 +/- 5.9%. After cessation of the somatostatin infusion there was a rise of plasma ACTH to starting levels within 1/2 hour. These findings suggest that somatostatin is a potent inhibitor of ACTH secretion, however, only in a condition in which glucocorticoids are lacking.
对5例不同病因所致肾上腺皮质功能不全的患者静脉注射生长抑素（单次推注250微克，随后1小时持续输注250微克）。在输注期间，每例患者血浆促肾上腺皮质激素（ACTH）均持续、进行性下降。血浆ACTH平均最大降幅为43.8±5.9%。生长抑素输注停止后，血浆ACTH在半小时内升至起始水平。这些结果提示，生长抑素是ACTH分泌的强效抑制剂，不过，仅在缺乏糖皮质激素的情况下如此。
