Bock K D, Nitzsche T
Klin Wochenschr. 1976 Mar 1;54(5):239-41. doi: 10.1007/BF01469132.
In 154 patients with phenacetin nephropathy and in 26 patients with phenacetin abuse but without nephropathy a laxative abuse was observed in 3.2% and 15.4%, hypokalemia (3.5 maequ/l or less) in 9.1% and 3.9, respectively. The mean plasma potassium concentration was normal in both groups (4.45 and 4.22 maequ/l, respectively). These data do not support the recently proposed hypothesis that the simultaneous abuse of laxatives contributes to the development of analgesic nephropathy, and that the absence of laxative intake might explain the lack of renal damage in some phenacetin abusers. Although it cannot be excluded that long-standing potassium deficiency in consequence of an abuse of laxatives or diuretics exerts an additional nephrotoxic effect in some cases, this mechanism seems not to be involved in the majority of patients with phenacetin nephropathy.
在154例非那西丁肾病患者以及26例滥用非那西丁但无肾病的患者中，分别有3.2%和15.4%存在泻药滥用情况，低钾血症（血钾浓度≤3.5毫当量/升）的发生率分别为9.1%和3.9%。两组患者的平均血浆钾浓度均正常（分别为4.45和4.22毫当量/升）。这些数据并不支持最近提出的假说，即同时滥用泻药会促使止痛剂肾病的发生，且未摄入泻药可能解释了部分非那西丁滥用者未出现肾损害的原因。尽管不能排除因滥用泻药或利尿剂导致的长期钾缺乏在某些情况下会产生额外的肾毒性作用，但在大多数非那西丁肾病患者中，这一机制似乎并不起作用。
