Beattie Kenneth A, Ressler Judith, Wiegand Claudia, Krause Eberhard, Codd Geoffrey A, Steinberg Christian E W, Pflugmacher Stephan
Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK.
Aquat Toxicol. 2003 Feb 12;62(3):219-26. doi: 10.1016/s0166-445x(02)00091-7.
The toxicity and metabolism of the cyanobacterial toxins microcystin-LR (MCLR), Dhb-microcystin-HtyR and nodularin were investigated in the cysts, nauplii and adults of the brine shrimp Artemia salina. The presence of the phase II detoxication system glutathione S-transferase (sGST) in these stages was shown using different substrates. Exposure of adult A. salina to the toxins led to an elevation of GST activity in vivo. All three toxins were conjugated to glutathione via GST, which has been shown as an initial step of microcystin and nodularin detoxication.
研究了蓝藻毒素微囊藻毒素-LR（MCLR）、Dhb-微囊藻毒素-HtyR和节球藻毒素在卤虫无节幼体、成体及其囊肿中的毒性和代谢情况。使用不同底物证明了这些阶段存在Ⅱ相解毒系统谷胱甘肽S-转移酶（sGST）。成年卤虫暴露于毒素会导致体内GST活性升高。所有这三种毒素都通过GST与谷胱甘肽结合，这已被证明是微囊藻毒素和节球藻毒素解毒的第一步。
