海藻酸钠-（聚-L-赖氨酸）-海藻酸钠微胶囊膜厚度的理论计算与实验研究

[Theoretical calculation and experimental study of membrane thickness of alginate-(poly-L-lysine)-alginate microcapsules].

作者信息

Sun Duoxian, Chen Yiqing, Yang Jun, Su Jing, Sun Anthony M

机构信息

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2002 Dec;19(4):645-7, 656.

PMID:12561369

Abstract

Alginate-(Poly-L-Lysine)-Alginate(APA) microcapsules were prepared by Electrostatic Droplet Generator(EDG) technique and the thickness of microcapsule membrane, which was composed by polyelectrolyte complex, were studied in this paper. The theoretical formula was given for the measurement of membrane thickness of APA microcapsules by element analysis of membrane and calculation. The membrane thickness was 7-10 microns by theoretical calculation. On the other hand, the thickness of membrane was measured by SEM and optical microscopy and the results were 7 microns and 12 microns, respectively. The results showed that theoretical calculation is in good accordance with experimental determoination of mermbrane thickness and the membrane thickness of APA microcapsule is about 7-10 microns. The optical microscopy is an easy way to measure membrane thickness.

摘要

采用静电液滴发生器（EDG）技术制备了海藻酸盐-（聚-L-赖氨酸）-海藻酸盐（APA）微胶囊，并对由聚电解质复合物组成的微胶囊膜厚度进行了研究。通过对膜的元素分析和计算，给出了测量APA微胶囊膜厚度的理论公式。理论计算得出膜厚度为7-10微米。另一方面，通过扫描电子显微镜（SEM）和光学显微镜测量膜厚度，结果分别为7微米和12微米。结果表明，膜厚度的理论计算与实验测定结果吻合良好，APA微胶囊的膜厚度约为7-10微米。光学显微镜是测量膜厚度的一种简便方法。